RGD Reference Report - Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. - Rat Genome Database

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Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.

Authors: Fernandez-de-las-Penas, C  Fernandez-Lao, C  Cantarero-Villanueva, I  Ambite-Quesada, S  Rivas-Martinez, I  Del Moral-Avila, R  Arroyo-Morales, M 
Citation: Fernandez-de-las-Penas C, etal., Breast Cancer Res Treat. 2012 Jun;133(2):405-12. doi: 10.1007/s10549-011-1757-y. Epub 2011 Sep 4.
RGD ID: 8662332
Pubmed: PMID:21898113   (View Abstract at PubMed)
DOI: DOI:10.1007/s10549-011-1757-y   (Journal Full-text)

Cancer-related fatigue and pain after surgery are the most frequent and most incapacitating cancer-related symptoms after breast cancer treatment. Genetic influence of cancer-related fatigue and pain has not been previously investigated. Our aim was to examine the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on cancer-related fatigue, post-mastectomy pain, and pressure pain hypersensitivity in breast cancer survivors. One-hundred and twenty-eight (n = 128) breast cancer survivors who were treated with radiotherapy and chemotherapy participated in this study. After amplifying Val158Met polymorphisms by polymerase chain reaction, COMT genotype was divided into Val/Val, valine/methionine (Val/Met), or Met/Met. The Piper fatigue scale (PFS) was used to assess cancer-related fatigue. Neck and shoulder/axillary pain intensity was assessed with a numerical pain rate scale (0-10). Finally, pressure pain thresholds (PPT) were assessed bilaterally over the C5-C6 zygapophyseal joints, deltoid muscles, second metacarpal, and tibialis anterior muscles. Breast cancer survivors carrying the Met/Met genotype reported higher levels of fatigue (all subscales, P < 0.001), higher neck pain intensity, and lower PPT over C5-C6 joints and deltoid muscles (all, P < 0.001) relative to those with Val/Met or Val/Val genotypes. The results suggest that breast cancer survivors carrying the Met/Met genotype exhibit higher fatigue, neck pain, and pressure pain hypersensitivity over the neck and shoulder area. This study is important because it strives to understand the factors that predispose some breast cancer survivors to more cancer-related fatigue and increased pain sensitivity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fatigue severityIAGP 8662332associated with breast cancer and DNA:missense mutation:cds:p.V158M (human)RGD 
Fatigue severityISOCOMT (Homo sapiens)8662332; 8662332associated with breast cancer and DNA:missense mutation:cds:p.V158M (human)RGD 
Neck Pain severityIAGP 8662332associated with breast cancer and DNA:missense mutation:cds:p.V158M (human)RGD 
Neck Pain severityISOCOMT (Homo sapiens)8662332; 8662332associated with breast cancer and DNA:missense mutation:cds:p.V158M (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neck pain severityIAGP 8662332associated with breast cancer and DNA:missense mutation:cds:p.V158MRGD 
Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information