RGD Reference Report - Human big-endothelin-1 and endothelin-1 release prostacyclin via the activation of ET1 receptors in the rat perfused lung. - Rat Genome Database

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Human big-endothelin-1 and endothelin-1 release prostacyclin via the activation of ET1 receptors in the rat perfused lung.

Authors: D'Orleans-Juste, P  Telemaque, S  Claing, A  Ihara, M  Yano, M 
Citation: D'Orleans-Juste P, etal., Br J Pharmacol. 1992 Apr;105(4):773-5.
RGD ID: 8662308
Pubmed: PMID:1324048   (View Abstract at PubMed)
PMCID: PMC1908696   (View Article at PubMed Central)

Although ET1 and ET2 binding sites were found in rat lung membranes, a selective ET1 receptor antagonist, BQ-123 (10 microM), did not displace [125I]-endothelin-1 ([125I]ET-1) from ET2 sites, illustrating the selectivity of the angatonist for ET1 receptors. In rat perfused lungs, BQ-123 (1 microM) markedly reduced the prostacyclin (PGI2) releasing properties of endothelin-1 (ET-1: 5 nM) and human big-ET-1 (100 nM) suggesting that both peptides induce the release of PGI2 via the selective activation of ET1 receptors.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of prostaglandin secretion  IDA 8662308 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)


Additional Information