RGD Reference Report - Beta-chemokine receptor expression in idiopathic inflammatory myopathies. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Beta-chemokine receptor expression in idiopathic inflammatory myopathies.

Authors: De Paepe, B  De Bleecker, JL 
Citation: De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
RGD ID: 8661727
Pubmed: PMID:15772970   (View Abstract at PubMed)
DOI: DOI:10.1002/mus.20294   (Journal Full-text)

Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DM), and control samples. CCR1-5 were localized to blood vessels in all samples. In addition, increased endothelial expression of CCR2A was observed in IIM. Subsets of inflammatory cells, identified as macrophages and T cells, in all three types of IIM expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In contrast to an earlier report, we found CCR2B to be the most prominent MCP-1 receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 expression was present on myonuclei of regenerating muscle fibers. The prominence of the CCR2 receptors further underlines the importance of the interaction with their ligand MCP-1 in the immunopathogenesis of IIM and puts CCR2B forward as a potential target for future therapeutic intervention.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dermatomyositis  IEP 8661727protein:increased expression:limb muscle:RGD 
dermatomyositis  ISOCCR2 (Homo sapiens)8661727; 8661727protein:increased expression:limb muscle:RGD 
inclusion body myositis  IEP 8661727protein:increased expression:limb muscle:RGD 
inclusion body myositis  ISOCCR2 (Homo sapiens)8661727; 8661727protein:increased expression:limb muscle:RGD 
polymyositis  IEP 8661727protein:increased expression:limb muscle:RGD 
polymyositis  ISOCCR2 (Homo sapiens)8661727; 8661727protein:increased expression:limb muscle:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)


Additional Information