RGD Reference Report - Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. - Rat Genome Database

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Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis.

Authors: Babich, PS  Tsymbalenko, NV  Masalova, OO  Platonova, NA  Shavlovskii, MM  Puchkova, LV  Sapronov, NS 
Citation: Babich PS, etal., Bull Exp Biol Med. 2009 Aug;148(2):217-22.
RGD ID: 8657017
Pubmed: PMID:20027333   (View Abstract at PubMed)

Fibrillogenesis was induced in rats by injection of a fragment of neurotoxic protein, beta-amyloid protein precursor, into the cerebral ventricle. Copper, iron, and zinc concentrations and relative activities of genes of copper-transporting protein and extracellular and intracellular cuproenzymes were evaluated in different brain compartments of these animals. Copper and zinc concentrations decreased significantly in different compartments of the brain of rats with experimental fibrillogenesis, while iron content did not change. According to the data of RT-PCR analysis, activities of genes of copper-transporting protein and extracellular coenzyme decreased. The expression of intracellular cuproenzyme genes and the content of SOD1 protein did not change, SOD1 activity in the cytosol decreased, and active SOD1 was detected in the mitochondrial intermembrane space. The relationship between fibrillogenesis and copper metabolism is discussed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  ISOAtp7a (Rattus norvegicus)8657017; 8657017mRNA:decreased expression:pituitary gland and vascular plexus (rat)RGD 
Alzheimer's disease  IEP 8657017mRNA:decreased expression:pituitary gland and vascular plexus (rat)RGD 
Alzheimer's disease  ISOSod1 (Rattus norvegicus)8657017; 8657017mRNA:altered expression:hippocampus and hypothalamus (rat)RGD 
Alzheimer's disease  IEP 8657017mRNA:altered expression:hippocampus and hypothalamus (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp7a  (ATPase copper transporting alpha)
Sod1  (superoxide dismutase 1)

Genes (Mus musculus)
Atp7a  (ATPase, Cu++ transporting, alpha polypeptide)
Sod1  (superoxide dismutase 1, soluble)

Genes (Homo sapiens)
ATP7A  (ATPase copper transporting alpha)
SOD1  (superoxide dismutase 1)


Additional Information