RGD Reference Report - Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. - Rat Genome Database

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Rab14 is involved in membrane trafficking between the Golgi complex and endosomes.

Authors: Junutula, JR  De Maziere, AM  Peden, AA  Ervin, KE  Advani, RJ  Van Dijk, SM  Klumperman, J  Scheller, RH 
Citation: Junutula JR, etal., Mol Biol Cell. 2004 May;15(5):2218-29. Epub 2004 Mar 5.
RGD ID: 8554557
Pubmed: PMID:15004230   (View Abstract at PubMed)
PMCID: PMC404017   (View Article at PubMed Central)
DOI: DOI:10.1091/mbc.E03-10-0777   (Journal Full-text)

Rab GTPases are localized to various intracellular compartments and are known to play important regulatory roles in membrane trafficking. Here, we report the subcellular distribution and function of Rab14. By immunofluorescence and immunoelectron microscopy, both endogenous as well as overexpressed Rab14 were localized to biosynthetic (rough endoplasmic reticulum, Golgi, and trans-Golgi network) and endosomal compartments (early endosomal vacuoles and associated vesicles). Notably overexpression of Rab14Q70L shifted the distribution toward the early endosome associated vesicles, whereas the S25N and N124I mutants induced a shift toward the Golgi region. A similar, although less pronounced, redistribution of the transferrin receptor was also observed in cells overexpressing Rab14 mutants. Impairment of Rab14 function did not however affect transferrin uptake or recycling kinetics. Together, these findings suggest that Rab14 is involved in the biosynthetic/recycling pathway between the Golgi and endosomal compartments.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Golgi to endosome transport involved_inTAS 8554557PMID:15004230UniProt 
intracellular transport involved_inNAS 8554557PMID:15004230UniProt 
vesicle-mediated transport involved_inNAS 8554557PMID:15004230UniProt 

Cellular Component

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GTPase activity enablesNAS 8554557PMID:15004230UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Rab14  (RAB14, member RAS oncogene family)


Additional Information