RGD Reference Report - SAP97 promotes the stability of Nax channels at the plasma membrane. - Rat Genome Database

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SAP97 promotes the stability of Nax channels at the plasma membrane.

Authors: Matsumoto, M  Fujikawa, A  Suzuki, R  Shimizu, H  Kuboyama, K  Hiyama, TY  Hall, RA  Noda, M 
Citation: Matsumoto M, etal., FEBS Lett. 2012 Nov 2;586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25.
RGD ID: 8554333
Pubmed: PMID:23022437   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2012.09.018   (Journal Full-text)

Na(x) is a sodium-level sensor for body fluids expressed in the circumventricular organs in the brain. Na(x) has a putative PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at the carboxyl (C)-terminus. Here we found that several PDZ proteins bind to Na(x) by PDZ-array overlay assay. Among them, synapse-associated protein 97 (SAP97/DLG1) was coexpressed with Na(x) in the subfornical organ. In C6 glioblastoma cells, destruction of the PDZ-binding motif of Na(x) or depletion of SAP97 resulted in a decrease in cell-surface Na(x), which was attenuated with inhibitors of endocytosis. These results indicate that SAP97 contributes to the stabilization of Na(x) channels at the plasma membrane.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:B1AYL18554333PMID:23022437IntAct 

Objects Annotated

Genes (Rattus norvegicus)
Dlg1  (discs large MAGUK scaffold protein 1)


Additional Information