RGD Reference Report - Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. - Rat Genome Database

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Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent.

Authors: Lavezzari, G  Roche, KW 
Citation: Lavezzari G and Roche KW, Neuropharmacology. 2007 Jan;52(1):100-7. Epub 2006 Aug 7.
RGD ID: 8554329
Pubmed: PMID:16890965   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuropharm.2006.07.011   (Journal Full-text)

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors (GPCRs) that are widely expressed throughout the brain and are involved in synaptic development, transmission, and plasticity. The endocytosis of several members of the GPCR superfamily of receptors, such as beta-adrenergic receptors, has been studied extensively. In contrast, the mechanisms regulating mGluR endocytosis and intracellular trafficking remain poorly defined. We describe here for the first time a distinct endocytic and intracellular sorting pathway utilized by mGluR7. We show that mGluR7 constitutively internalizes via a non-clathrin mediated pathway in heterologous cells and in neurons. Unlike clathrin-mediated NMDAR endocytosis, mGluR7 traffics via an Arf6-positive endosomal pathway, similar to other well-characterized proteins such as major histocompatibility complex class I (MHC I) and the GPI-anchored protein CD59. Thus constitutive endocytosis of mGluR7 in neurons is not regulated by clathrin-dependent mechanisms, and this clathrin-independent pathway ultimately determines the amount of receptor present on the plasma membrane available to bind and respond to glutamate.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell surface located_inIDA 8554329PMID:16890965UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Grm7  (glutamate metabotropic receptor 7)


Additional Information