RGD Reference Report - A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. - Rat Genome Database

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A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis.

Authors: Osterweil, E  Wells, DG  Mooseker, MS 
Citation: Osterweil E, etal., J Cell Biol. 2005 Jan 17;168(2):329-38.
RGD ID: 8554291
Pubmed: PMID:15657400   (View Abstract at PubMed)
PMCID: PMC2171578   (View Article at PubMed Central)
DOI: DOI:10.1083/jcb.200410091   (Journal Full-text)

Myosin VI (Myo6) is an actin-based motor protein implicated in clathrin-mediated endocytosis in nonneuronal cells, though little is known about its function in the nervous system. Here, we find that Myo6 is highly expressed throughout the brain, localized to synapses, and enriched at the postsynaptic density. Myo6-deficient (Snell's waltzer; sv/sv) hippocampus exhibits a decrease in synapse number, abnormally short dendritic spines, and profound astrogliosis. Similarly, cultured sv/sv hippocampal neurons display decreased numbers of synapses and dendritic spines, and dominant-negative disruption of Myo6 in wild-type hippocampal neurons induces synapse loss. Importantly, we find that sv/sv hippocampal neurons display a significant deficit in the stimulation-induced internalization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors (AMPARs), and that Myo6 exists in a complex with the AMPAR, AP-2, and SAP97 in brain. These results suggest that Myo6 plays a role in the clathrin-mediated endocytosis of AMPARs, and that its loss leads to alterations in synaptic structure and astrogliosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synapse located_inIDA 8554291PMID:15657400MGI 

Objects Annotated

Genes (Rattus norvegicus)
Dlg4  (discs large MAGUK scaffold protein 4)


Additional Information