RGD Reference Report - Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. - Rat Genome Database

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Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons.

Authors: Chen, Y  Li, M 
Citation: Chen Y and Li M, Neuropharmacology. 2005 Dec;49(7):1026-41. Epub 2005 Jul 28.
RGD ID: 8554049
Pubmed: PMID:16054660   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuropharm.2005.05.022   (Journal Full-text)

The integrity of dynamic actin structures is coupled to a variety of neurological processes. Actin-binding proteins play a critical role in regulating actin structure dynamics. A link between actin-binding proteins and receptor interacting scaffolding proteins may provide a conduit for transmitting signaling events to the cytoskeleton. Actinfilin is a brain-enriched actin-binding protein, though its functions are currently unknown. We report here that actinfilin interacts with the multi-PDZ domain protein CAP70. Recombinant expression of an actin-binding domain of actinfilin progressively causes marked changes of cellular morphology. The effect on cell morphology may be reduced by co-expression with CAP70. Mutation of actinfilin lacking the ability to interact with CAP70 abolished the effect by CAP70. The evidence suggests a role of actinfilin and possible regulation by scaffolding proteins.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
actin cytoskeleton organization involved_inIDA 8554049PMID:16054660UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
actin cytoskeleton located_inIDA 8554049PMID:16054660UniProt 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Dlg4  (discs large MAGUK scaffold protein 4)
Grin1  (glutamate ionotropic receptor NMDA type subunit 1)
Klhl17  (kelch-like family member 17)
Pdzk1  (PDZ domain containing 1)
Syngap1  (synaptic Ras GTPase activating protein 1)


Additional Information