RGD Reference Report - Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. - Rat Genome Database

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Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.

Authors: Aboulaich, N  Ortegren, U  Vener, AV  Stralfors, P 
Citation: Aboulaich N, etal., Biochem Biophys Res Commun. 2006 Nov 24;350(3):657-61. Epub 2006 Sep 28.
RGD ID: 8553552
Pubmed: PMID:17026959   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.09.094   (Journal Full-text)

Polymerase I and transcript release factor (PTRF) is in human adipocytes mainly localized at the plasma membrane. This localization was under control of insulin, which translocated PTRF to the cytosol and nucleus, indicating a novel role for PTRF in insulin transcriptional control. In the plasma membrane PTRF was specifically bound to a triacylglycerol-metabolizing subclass of caveolae containing hormone-sensitive lipase (HSL). In response to insulin PTRF was translocated to the cytosol in parallel with HSL. PTRF and HSL were quantitatively immunoprecipitated from the cytosol by antibodies against either PTRF or HSL. The findings indicate also a novel extranuclear function for PTRF in the control of lipolysis.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
caveola located_inISSUniProtKB:Q6NZI28553552PMID:17026959UniProt 
cytoplasm located_inISSUniProtKB:Q6NZI28553552; 8553552PMID:17026959UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Cavin1  (caveolae associated protein 1)
Lipe  (lipase E, hormone sensitive type)


Additional Information