RGD Reference Report - Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. - Rat Genome Database

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Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse.

Authors: Brandstatter, JH  Koulen, P  Kuhn, R  Van der Putten, H  Wassle, H 
Citation: Brandstatter JH, etal., J Neurosci. 1996 Aug 1;16(15):4749-56.
RGD ID: 8553461
Pubmed: PMID:8764662   (View Abstract at PubMed)
PMCID: PMC6579013   (View Article at PubMed Central)

The distribution of the metabotropic glutamate receptor 7 (mGluR7) was studied in the rat retina using a specific antiserum. Punctate immunofluorescence that corresponded to synaptic localization was present exclusively in the inner plexiform layer. Double-labeling experiments suggested that mGluR7 is expressed at the synaptic terminals of certain cone bipolar cells. Electron microscopy showed that mGluR7 was present both presynaptically, as an autoreceptor in cone bipolar cell ribbon synapses, and postsynaptically in amacrine cells. There are usually two postsynaptic processes at a bipolar cell ribbon synapse; however, the presynaptic aggregation of mGluR7 was restricted to one half of the active zone and therefore was opposed to only one of the postsynaptic processes. This selective localization of mGluR7 could differentially regulate the glutamate release from the ribbon synapse, thus leading to a differential activation of the postsynaptic neurons.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic membrane located_inIDA 8553461PMID:8764662UniProt 
presynaptic active zone located_inIDA 8553461PMID:8764662UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Grm7  (glutamate metabotropic receptor 7)


Additional Information