RGD Reference Report - Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. - Rat Genome Database

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Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis.

Authors: Kang, HJ  Cinn, YG  Hwang, SJ  Won Chae, S  Woo, JS  Lee, SH  Lee, HM 
Citation: Kang HJ, etal., Arch Otolaryngol Head Neck Surg. 2006 Nov;132(11):1196-200.
RGD ID: 8552811
Pubmed: PMID:17116814   (View Abstract at PubMed)
DOI: DOI:10.1001/archotol.132.11.1196   (Journal Full-text)

OBJECTIVES: To investigate the expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) messenger RNA and protein and to localize the PPAR-gamma protein in the nasal mucosa of patients with allergic rhinitis and control subjects. DESIGN: Prospective study. SETTING: Tertiary academic institution. Patients Twenty patients with perennial allergic rhinitis and 20 matched nonallergic patients. INTERVENTIONS: Inferior turbinate mucosa samples were obtained from 20 patients with perennial allergic rhinitis and 20 matched nonallegic patients. Peroxisome proliferator-activated receptor gamma messenger RNA was extracted from the inferior turbinate mucosae, and then reverse transcription-polymerase chain reaction was performed. Western blot testing was used to analyze differences in PPAR-gamma protein expression levels between patients with allergic rhinitis and normal controls, and the PPAR-gamma protein was localized immunohistochemically. RESULTS: The expression levels of PPAR-gamma messenger RNA and protein in the nasal mucosa was significantly increased in patients with perennial allergic rhinitis compared with controls. Peroxisome proliferator-activated receptor gamma protein was expressed in the epithelium, infiltrating inflammatory cells, and submucosal glands. CONCLUSIONS: Peroxisome proliferator-activated receptor gamma is expressed in the human nasal mucosa and is up-regulated in perennial allergic rhinitis. These results suggest a possible contribution for PPAR-gamma in chronic inflammation of the nasal mucosa in perennial allergic rhinitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Perennial Allergic Rhinitis  IEP 8552811mRNA and protein:increased expression:nasal mucosa (human)RGD 
Perennial Allergic Rhinitis  ISOPPARG (Homo sapiens)8552811; 8552811mRNA and protein:increased expression:nasal mucosa (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pparg  (peroxisome proliferator-activated receptor gamma)

Genes (Mus musculus)
Pparg  (peroxisome proliferator activated receptor gamma)

Genes (Homo sapiens)
PPARG  (peroxisome proliferator activated receptor gamma)


Additional Information