RGD Reference Report - Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents. - Rat Genome Database

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Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents.

Authors: Jokanovic, M 
Citation: Jokanovic M Toxicol Lett. 2009 Jul 10;188(1):1-10. doi: 10.1016/j.toxlet.2009.03.017. Epub 2009 Mar 31.
RGD ID: 8551792
Pubmed: PMID:19433263   (View Abstract at PubMed)
DOI: DOI:10.1016/j.toxlet.2009.03.017   (Journal Full-text)

This study reviews current understanding of chemical, biochemical and toxicological aspects and mechanisms of metabolism of warfare nerve agents. Among enzymes participating in metabolism of nerve agents the role of A-esterases, serum cholinesterase and carboxylesterases is discussed. This article also discusses other aspects of metabolism of the agents such as protein binding and the role of tissue depots for these compounds.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
organophosphate response pathway   TAS 8551792 RGD 
organophosphate response pathway   ISOOR10H3 (Homo sapiens)8551792; 8551792 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)

Genes (Mus musculus)
Pon1  (paraoxonase 1)

Genes (Homo sapiens)
PON1  (paraoxonase 1)


Additional Information