RGD Reference Report - Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein. - Rat Genome Database

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Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein.

Authors: Biswas, PS  Banerjee, K  Zheng, M  Rouse, BT 
Citation: Biswas PS, etal., J Leukoc Biol. 2004 Oct;76(4):868-75. Epub 2004 Jul 16.
RGD ID: 8549793
Pubmed: PMID:15258192   (View Abstract at PubMed)
DOI: DOI:10.1189/jlb.0504280   (Journal Full-text)

Herpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis. The present study evaluates the efficacy of IL-1 receptor antagonist (IL-1 ra) protein in the management of HSK. Mice receiving IL-1 ra had diminished disease severity. The administration of IL-1 ra was shown to reduce the influx into the cornea of cells of the innate and adaptive immune response. In addition, the treatment diminished corneal vascular endothelial growth factor levels, resulting in reduced angiogenic response. Our results show the importance of targeting early proinflammatory molecules such as IL-1 to counteract HSK and advocate IL-1 ra as an effective agent to achieve this.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
herpes simplex virus keratitis treatmentIDA 8549793human protein in a mouse modelRGD 
herpes simplex virus keratitis treatmentISOIL1RN (Homo sapiens)8549793; 8549793human protein in a mouse modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Mus musculus)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Homo sapiens)
IL1RN  (interleukin 1 receptor antagonist)


Additional Information