RGD Reference Report - IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma. - Rat Genome Database

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IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma.

Authors: Deepak, P  Kumar S, JR  Kishore, D  Acharya, A 
Citation: Deepak P, etal., Int Immunol. 2010 Jan;22(1):53-63. doi: 10.1093/intimm/dxp114. Epub 2009 Nov 30.
RGD ID: 8549563
Pubmed: PMID:19951958   (View Abstract at PubMed)
DOI: DOI:10.1093/intimm/dxp114   (Journal Full-text)

Dalton's lymphoma (DL) is a transplantable T-cell lymphoma of spontaneous origin, characterized by highly invasive and immunosuppressive property. Progression of DL cells results into an imbalance of T helper type 1 (T(h)1)/T helper type 2 (T(h)2)-type cytokine in the host, which is partly responsible for DL-induced severe immunosuppression and DL cell progression. In this study, we have shown the role of IL-13 in the regulation of T(h)1 immunity in both normal healthy and DL-bearing host. IL-13 pre-treatment inhibits the induction of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity and delayed-type hypersensitivity (DTH) in antigen-challenged mice, which have been confirmed by neutralizing IL-13 by systemic delivery of non-signaling decoy receptor IL-13Ralpha2. Furthermore, IL-13 neutralization enhances the splenocyte proliferation, which has been inhibited by IL-13 administration. Adoptive transfer of splenocyte from IL-13-pre-treated mice and macrophages incubated with IL-13 and pulsed with antigens suppresses the DTH as well in antigen-challenged recipient mice. In addition, it also suppresses the production of pro-inflammatory cytokine and C-C chemokine in DTH footpad. Furthermore, IL-13 neutralization not only enhances the DTH reaction but also increases longevity and survival of DL-bearing host, which suggests that blocking/inactivating systemic IL-13 enhances T(h)1 immunity, and therefore, effects to diminish IL-13 production may have therapeutic value in a host bearing T-cell lymphoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)
Il13ra2  (interleukin 13 receptor subunit alpha 2)

Genes (Mus musculus)
Il13  (interleukin 13)
Il13ra2  (interleukin 13 receptor, alpha 2)

Genes (Homo sapiens)
IL13  (interleukin 13)
IL13RA2  (interleukin 13 receptor subunit alpha 2)


Additional Information