RGD Reference Report - Increased level of interleukin-13, but not interleukin-4 and interferon-gamma in chronic rhinosinusitis with nasal polyps. - Rat Genome Database

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Increased level of interleukin-13, but not interleukin-4 and interferon-gamma in chronic rhinosinusitis with nasal polyps.

Authors: Nabavi, M  Arshi, S  Bahrami, A  Aryan, Z  Bemanian, MH  Esmaeilzadeh, H  Jalali, F  Pousti, SB  Rezaei, N 
Citation: Nabavi M, etal., Allergol Immunopathol (Madr). 2013 Aug 19. pii: S0301-0546(13)00192-4. doi: 10.1016/j.aller.2013.06.007.
RGD ID: 8549540
Pubmed: PMID:23969075   (View Abstract at PubMed)
DOI: DOI:10.1016/j.aller.2013.06.007   (Journal Full-text)

BACKGROUND: This study was performed to investigate the serum level of interleukin (IL)-13, IL-4, and interferon (IFN)-gamma in chronic rhinosinusitis with nasal polyps (CRSwNP) and subsequent inflammation pattern and comorbidities including asthma and aspirin intolerance. METHODS: A case-control study was conducted on 60 adult patients with CRSwNP with mean age of 37.7+/-12.7 (ranging from 18 to 70) years, and on 20 healthy controls. Serum levels of IL-13, IL-4, and IFN-gamma were assessed, using enzyme-linked immunosorbent assay to be compared between case and control groups. Serum level of total immunoglobulin (Ig) E was also assessed in the patients with CRSwNP. RESULTS: Serum level of IL-13 in the patients with CRSwNP was significantly higher than the controls (0.98+/-1.56 vs. 0.34+/-0.16 pg/ml, respectively, p=0.002). IL-4 and IFN-gamma did not differ significantly between the two groups. Total IgE level was significantly increased in the patients with CRSwNP, compared to the normal values (301.43+/-516.54 IU/ml, p=0.033). Among the patients with CRSwNP, 12/60 (20%) had aspirin intolerance and 44/60 (73.3%) had asthma. IgE was also higher in asthmatics than non-asthmatics patients (364.9+/-586.6 vs. 126.7+/-135.7, respectively, p=0.015). Patients with aspirin intolerance had higher levels of IFN-gamma (4.7+/-1.4 vs. 4.1+/-0.6, respectively, p=0.022). CONCLUSIONS: IL-13 with high level of total IgE was observed in the patients with CRSwNP, which predisposes them to have concomitant asthma. IFN-gamma seems to be down-regulated in the patients with CRSwNP, but could be over-expressed in the presence of aspirin intolerance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nasal Polyps  IEP 8549540associated with Rhinosinusitis and protein:increased expression:serumRGD 
Nasal Polyps  ISOIL13 (Homo sapiens)8549540; 8549540associated with Rhinosinusitis and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)

Genes (Mus musculus)
Il13  (interleukin 13)

Genes (Homo sapiens)
IL13  (interleukin 13)


Additional Information