RGD Reference Report - Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. - Rat Genome Database

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Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure.

Authors: Zong, WN  Yang, XH  Chen, XM  Huang, HJ  Zheng, HJ  Qin, XY  Yong, YH  Cao, K  Huang, J  Lu, XZ 
Citation: Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
RGD ID: 8549482
Pubmed: PMID:21963897   (View Abstract at PubMed)
PMCID: PMC4002738   (View Article at PubMed Central)
DOI: DOI:10.1038/aps.2011.96   (Journal Full-text)

AIM: To investigate the possible effects of telmisartan and losartan on cardiac function in adriamycin (ADR)-induced heart failure in rats, and to explore the changes in plasma level of angiotensin-(1-7)[Ang-(1-7)] and myocardial expression of angiotensin II type 1/2 receptors (AT(1)R / AT(2)R) and Mas receptor caused by the two drugs. METHODS: Male Sprague-Dawley rats were randomly divided into 4 groups: the control group, ADR-treated heart failure group (ADR-HF), telmisartan plus ADR-treated group (Tel+ADR) and losartan plus ADR-treated group (Los+ADR). ADR was administrated (2.5 mg/kg, ip, 6 times in 2 weeks). The rats in the Tel+ADR and Los+ADR groups were treated orally with telmisartan (10 mg/kg daily po) and losartan (30 mg/kg daily), respectively, for 6 weeks. The plasma level of Ang-(1-7) was determined using ELISA. The mRNA and protein expression of myocardial Mas receptor, AT(1)R and AT(2)R were measured using RT-PCR and Western blotting, respectively. RESULTS: ADR significantly reduced the plasma level of Ang-(1-7) and the expression of myocardial Mas receptor and myocardial AT(2)R, while significantly increased the expression of myocardial AT(1)R. Treatment with telmisartan and losartan effectively increased the plasma level of Ang-(1-7) and suppressed myocardial AT(1)R expression, but did not influence the expression of Mas receptor and AT(2)R. CONCLUSION: The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
congestive heart failure treatmentISOAgt (Rattus norvegicus)8549482; 8549482 RGD 
congestive heart failure treatmentISOAgtr1a (Rattus norvegicus)8549482; 8549482 RGD 
congestive heart failure  ISOAgtr2 (Rattus norvegicus)8549482; 8549482mRNA and protein:decreased expression:heartRGD 
congestive heart failure treatmentIEP 8549482 RGD 
congestive heart failure treatmentIMP 8549482 RGD 
congestive heart failure  IEP 8549482; 8549482mRNA and protein:decreased expression:heartRGD 
congestive heart failure  ISOMas1 (Rattus norvegicus)8549482; 8549482mRNA and protein:decreased expression:heartRGD 

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)
Agtr1a  (angiotensin II receptor, type 1a)
Agtr2  (angiotensin II receptor, type 2)
Mas1  (MAS1 proto-oncogene, G protein-coupled receptor)

Genes (Mus musculus)
Agt  (angiotensinogen)
Agtr1a  (angiotensin II receptor, type 1a)
Agtr2  (angiotensin II receptor, type 2)
Mas1  (MAS1 oncogene)

Genes (Homo sapiens)
AGT  (angiotensinogen)
AGTR1  (angiotensin II receptor type 1)
AGTR2  (angiotensin II receptor type 2)
MAS1  (MAS1 proto-oncogene, G protein-coupled receptor)


Additional Information