RGD Reference Report - Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease. - Rat Genome Database

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Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease.

Authors: Maiorano, E  Perlino, E  Triggiani, V  Nacchiero, M  Giove, E  Ciampolillo, A 
Citation: Maiorano E, etal., Int J Mol Med. 1998 Oct;2(4):483-6.
RGD ID: 8548837
Pubmed: PMID:9857239   (View Abstract at PubMed)

Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this growth factor in the pathogenesis of hyperplastic thyroid lesions, we investigated the expression of IGF-1 and of its corresponding receptor, by means of immunohistochemistry, in the surgical specimens obtained from six patients with Graves' disease. Moreover, IGF-1 mRNA expression was analysed in one such case by means of Northern hybridisation. All samples showed consistent intracytoplasmic immunoreactivity for both IGF-1 and IGF-1 receptor; the vast majority of hyperplastic thyrocytes were strongly decorated by the two antibodies used in this study whereas stromal cells displayed IGF-1 immunoreactivity only. IGF-1 mRNA was markedly overexpressed in Graves' disease in comparison with normal thyroid tissues. The results of this study suggest that IGF-1 and IGF-1 receptor may be actively involved in the pathogenesis of Graves' disease; furthermore, IGF-1 and IGF-1 receptor apparently act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Graves' disease  IEP 8548837mRNA and protein:increased expression:thyroid gland:RGD 
Graves' disease  ISOIGF1 (Homo sapiens)8548837; 8548837mRNA and protein:increased expression:thyroid gland:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information