RGD Reference Report - Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. - Rat Genome Database

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Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.

Authors: Ho, HT  Chung, SK  Law, JW  Ko, BC  Tam, SC  Brooks, HL  Knepper, MA  Chung, SS 
Citation: Ho HT, etal., Mol Cell Biol. 2000 Aug;20(16):5840-6.
RGD ID: 8548674
Pubmed: PMID:10913167   (View Abstract at PubMed)
PMCID: PMC86061   (View Article at PubMed Central)

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nephrogenic diabetes insipidus  ISOAkr1b1 (Mus musculus)8548674; 8548674 RGD 
nephrogenic diabetes insipidus  IMP 8548674 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akr1b1  (aldo-keto reductase family 1 member B1)

Genes (Mus musculus)
Akr1b1  (aldo-keto reductase family 1 member B)

Genes (Homo sapiens)
AKR1B1  (aldo-keto reductase family 1 member B)


Additional Information