RGD Reference Report - Levels of vascular endothelial growth factor and hepatocyte growth factor in sera of patients with rheumatic diseases. - Rat Genome Database

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Levels of vascular endothelial growth factor and hepatocyte growth factor in sera of patients with rheumatic diseases.

Authors: Hashimoto, N  Iwasaki, T  Kitano, M  Ogata, A  Hamano, T 
Citation: Hashimoto N, etal., Mod Rheumatol. 2003 Jun;13(2):129-34. doi: 10.3109/s10165-002-0211-8.
RGD ID: 8548659
Pubmed: PMID:24387171   (View Abstract at PubMed)
DOI: DOI:10.3109/s10165-002-0211-8   (Journal Full-text)

Abstract Angiogenesis plays an important role in the progression of rheumatic disease. We measured the levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in sera from patients with rheumatic diseases and investigated whether these angiogenic factors would be useful in the evaluation of rheumatic diseases. Serum VEGF and HGF levels were determined using ELISA in 128 patients with rheumatic diseases and in 11 healthy controls. Serum VEGF and HGF levels were significantly higher in patients with rheumatic diseases compared to healthy controls [VEGF, 312 +/- 20 pg/ml versus 61 +/- 8 pg/ml (mean +/- SE), P < 0.001; HGF, 935 +/- 36 pg/ml versus 413 +/- 49 pg/ml, P < 0.01]. Serum VEGF and HGF levels were significantly elevated in patients with adult Still's disease (VEGF, 1021 +/- 258 pg/ml; HGF, 1500 +/- 295 pg/ml) and were relatively increased in patients with active rheumatoid arthritis (RA) (VEGF, 359 +/- 94 pg/ml) and systemic sclerosis (SSc) (VEGF, 356 +/- 43 pg/ml; HGF, 1294 +/- 224 pg/ml). HGF levels correlated with the clinical course and disease severity in rheumatic disease patients. VEGF levels correlated with the presence of Raynaud's phenomenon (P < 0.05), interstitial lung disease (ILD) (P < 0.05), and serum KL-6 levels (P < 0.01), whereas HGF levels correlated with cryoglobulinemia (P < 0.05), ILD (P < 0.05), serum C-reactive protein (CRP) (P < 0.05), thrombomodulin (P < 0.05), and KL-6 levels (P < 0.05) in rheumatic disease patients. VEGF levels correlated with the skin scores and KL-6 levels in SSc patients and also correlated with the disease activity of RA patients. These data suggest that serum VEGF and HGF levels are related to rheumatic disease activity and the presence of complications. Analysis of VEGF and HGF may be useful in the clinical evaluation of rheumatic disease patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
adult-onset Still's disease  IEP 8548659; 8548659protein:increased expression:serum:RGD 
adult-onset Still's disease  ISOHGF (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 
adult-onset Still's disease  ISOVEGFA (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 
rheumatoid arthritis disease_progressionIEP 8548659; 8548659protein:increased expression:serum:RGD 
rheumatoid arthritis disease_progressionISOHGF (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 
rheumatoid arthritis disease_progressionISOVEGFA (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 
systemic scleroderma  IEP 8548659; 8548659protein:increased expression:serum:RGD 
systemic scleroderma  ISOHGF (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 
systemic scleroderma  ISOVEGFA (Homo sapiens)8548659; 8548659protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)
VEGFA  (vascular endothelial growth factor A)


Additional Information