RGD Reference Report - Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease. - Rat Genome Database

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Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease.

Authors: Sapin, R  D'Herbomez, M  Gasser, F  Meyer, L  Schlienger, JL 
Citation: Sapin R, etal., Clin Biochem. 2003 Nov;36(8):611-6.
RGD ID: 8548606
Pubmed: PMID:14636875   (View Abstract at PubMed)

OBJECTIVES: To verify the cut-off values and to determine the clinical sensitivity of antithyroglobulin (TgAb) determinations using our routine RIA and the new electrochemiluminescent Elecsys assay. DESIGN AND METHODS: We used the DYNOtest anti-Tgn manual RIA from BRAHMS and the new automated Elecsys electrochemiluminescent immunoassay from Roche Diagnostics. We analyzed 452 sera from the following subjects: 193 euthyroid controls, 163 with treated and untreated autoimmune thyroid diseases (AITD) (108 Graves' disease and 55 thyroiditis), 50 with differentiated thyroid carcinoma, 13 with nonautoimmune thyroid disease and 33 with type 1 diabetes mellitus. RESULTS: As expected, using the proposed thresholds (BRAHMS 60 kIU/L, Elecsys 115 kIU/L) approximately 6% of the control subjects were positive for TgAb with both methods. In AITD patients, the sensitivity of TgAb determination was significantly higher with the Elecsys assay (51.5%) than with the BRAHMS assay (39.3%). This difference was not observed in the other patient groups. CONCLUSION: The Elecsys assay can be preferred not only because it is automated and rapid, but also because of its better clinical performance in AITD patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Graves' disease  IDA 8548606 RGD 
Graves' disease  ISOTG (Homo sapiens)8548606; 8548606 RGD 
Hashimoto Disease  IDA 8548606 RGD 
Hashimoto Disease  ISOTG (Homo sapiens)8548606; 8548606 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tg  (thyroglobulin)

Genes (Mus musculus)
Tg  (thyroglobulin)

Genes (Homo sapiens)
TG  (thyroglobulin)


Additional Information