RGD Reference Report - Association of beta 2-adrenergic receptor polymorphism with the phenotype of aspirin-intolerant acute urticaria. - Rat Genome Database

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Association of beta 2-adrenergic receptor polymorphism with the phenotype of aspirin-intolerant acute urticaria.

Authors: Kim, HA  Ye, YM  Kim, SH  Hur, GY  Park, HS 
Citation: Kim HA, etal., Yonsei Med J. 2007 Dec 31;48(6):1079-81.
RGD ID: 8548486
Pubmed: PMID:18159608   (View Abstract at PubMed)
PMCID: PMC2628181   (View Article at PubMed Central)
DOI: DOI:10.3349/ymj.2007.48.6.1079   (Journal Full-text)

The genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the beta 2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria (AICU), and 498 normal healthy controls (NC) based on a Korean population were enrolled. The genotype of ADRB2 at 46 A > G was analyzed using a direct sequencing method. The ADRB2 polymorphism at 46 A > G showed a significant difference between AIAU and NC; the frequency of the major genotype was significantly higher in the AIAU group (p= 0.017 in recessive model), while no differences were noted in allele and genotype frequencies between AICU and NC. In conclusion, the ADRB2 (46 A > G) gene polymorphism may contribute to the development of the phenotype of AIAU.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urticaria susceptibilityIAGP 8548486DNA:polymorphism: :46A>G(human)RGD 
urticaria susceptibilityISOADRB2 (Homo sapiens)8548486; 8548486DNA:polymorphism: :46A>G(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)

Genes (Mus musculus)
Adrb2  (adrenergic receptor, beta 2)

Genes (Homo sapiens)
ADRB2  (adrenoceptor beta 2)


Additional Information