RGD Reference Report - Expression of angiogenic factors in neurofibromas. - Rat Genome Database

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Expression of angiogenic factors in neurofibromas.

Authors: Kawachi, Y  Xu, X  Ichikawa, E  Imakado, S  Otsuka, F 
Citation: Kawachi Y, etal., Exp Dermatol. 2003 Aug;12(4):412-7.
RGD ID: 8547970
Pubmed: PMID:12930297   (View Abstract at PubMed)

We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis-1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT-PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neurofibromatosis 1  IEP 8547970mRNA and protein:increased expression:dermisRGD 
neurofibromatosis 1  ISOVEGFA (Homo sapiens)8547970; 8547970mRNA and protein:increased expression:dermisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information