RGD Reference Report - Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach. - Rat Genome Database

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Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach.

Authors: Rodenburg, W  Pennings, JL  Van Oostrom, CT  Roodbergen, M  Kuiper, RV  Luijten, M  De Vries, A 
Citation: Rodenburg W, etal., Proteomics Clin Appl. 2010 Jul;4(6-7):603-12. doi: 10.1002/prca.200900175. Epub 2010 Mar 24.
RGD ID: 8547744
Pubmed: PMID:21137078   (View Abstract at PubMed)
DOI: DOI:10.1002/prca.200900175   (Journal Full-text)

PURPOSE: Transgenic mouse models for cancer circumvent many challenges that hamper human studies aimed at biomarker discovery. Lower biological variances among mice combined with controllable factors such as food uptake and health status may enable the detection of more subtle protein expression differences. This is envisioned to result in the identification of biomarkers better discriminating cancer cases from controls. EXPERIMENTAL DESIGN: The current study used two innovative mouse models for breast-cancer to identify new serum biomarkers. Multi-analyte profiling technique was used to analyze 70 proteins in individual serum samples of non-tumor and mammary tumor-bearing Tg.NK (MMTV/c-neu) mice. RESULTS: A small set of proteins fully differentiated tumor samples from controls. These comprised osteopontin, interleukin-18, cystatin C and CD40 antigen. Comparison of protein expression in another breast-cancer mouse model, the humanized p53.R270H mice, showed common discriminatory expression of osteopontin. However, other biomarkers showed distinct expression in the two different breast-cancer models, indicating that different mammary tumor sub-types with respect to molecular and estrogen receptor status reveal divergent serum biomarker sets. CONCLUSIONS AND CLINICAL RELEVANCE: The current study supports the concept that serum proteins can discriminate mammary tumor cases from controls, and yielded interesting biomarkers that need further testing and validation in human studies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms  ISOCd40 (Mus musculus)8547744; 8547744 RGD 
Experimental Mammary Neoplasms  IEP 8547744 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)

Genes (Mus musculus)
Cd40  (CD40 antigen)

Genes (Homo sapiens)
CD40  (CD40 molecule)


Additional Information