RGD Reference Report - Actin in hair cells and hearing loss. - Rat Genome Database

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Actin in hair cells and hearing loss.

Authors: Drummond, MC  Belyantseva, IA  Friderici, KH  Friedman, TB 
Citation: Drummond MC, etal., Hear Res. 2012 Jun;288(1-2):89-99. doi: 10.1016/j.heares.2011.12.003. Epub 2011 Dec 13.
RGD ID: 8547677
Pubmed: PMID:22200607   (View Abstract at PubMed)
PMCID: PMC3403717   (View Article at PubMed Central)
DOI: DOI:10.1016/j.heares.2011.12.003   (Journal Full-text)

Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system.


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