RGD Reference Report - Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction. - Rat Genome Database

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Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction.

Authors: Peng, AW  Salles, FT  Pan, B  Ricci, AJ 
Citation: Peng AW, etal., Nat Commun. 2011 Nov 1;2:523. doi: 10.1038/ncomms1533.
RGD ID: 8547676
Pubmed: PMID:22045002   (View Abstract at PubMed)
PMCID: PMC3418221   (View Article at PubMed Central)
DOI: DOI:10.1038/ncomms1533   (Journal Full-text)

Mechanosensation is a primitive and somewhat ubiquitous sense. At the inner ear, sensory hair cells are refined to enhance sensitivity, dynamic range and frequency selectivity. Thirty years ago, mechanisms of mechanotransduction and adaptation were well accounted for by simple mechanical models that incorporated physiological and morphological properties of hair cells. Molecular and genetic tools, coupled with new optical techniques, are now identifying and localizing specific components of the mechanotransduction machinery. These new findings challenge long-standing theories, and require modification of old and development of new models. Future advances require the integration of molecular and physiological data to causally test these new hypotheses.


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