RGD Reference Report - [Possible association between polymorphisms of human leukocyte antigen-DQ genes and susceptibility to trichloroethylene-induced severe generalized dermatitis].

General

[Possible association between polymorphisms of human leukocyte antigen-DQ genes and susceptibility to trichloroethylene-induced severe generalized dermatitis].
Authors:	Li, HS Dai, YF Huang, HL Feng, XL Sun, YF Niu, Y Cheng, J Zhang, LY Li, LY Chen, B Zheng, YX
Citation:	Li HS, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2006 May;40(3):173-6.
RGD ID:	8547665
Pubmed:	PMID:16836882 (View Abstract at PubMed)
OBJECTIVE: To investigate the association between genetic polymorphisms of human leukocyte antigen-DQ (HLA-DQ) and susceptibility to trichloroethylene (TCE)-induced severe generalized dermatitis. METHODS: A case-control study was conducted which included 112 patients with TCE-induced severe generalized dermatitis and 142 healthy controls exposed to TCE in the same workshop. The DNA sequences in exon2 of HLA-DQA1 and HLA-DQB1 were performed by direct sequencing of polymerase chain reaction (PCR) products. The frequencies distribution of allelic genotypes and codon polymorphisms were compared. RESULTS: The frequencies of DQA10201 and 060101/0602 in cases [7.6% (17/224) and 16.1% (36/224)] were significantly higher than those of the exposed controls [3.5% (10/284) and 7.0% (20/284)], while frequencies of DQA10103 and 050101/0503/0505 in cases [5.8% (13/224) and 8.9% (20/224)] were significantly lower than those of exposed controls [10.9% (31/284) and 17.3% (49/284)]. In terms of codon polymorphisms, there were 5 codons of DQA1 (25, 41, 52, 54 and 69) showing significant differences between cases and controls. There were no significant differences in the frequencies of allelic genotypes of HLA-DQB1 between cases and exposed controls. CONCLUSION: The genetic polymorphisms of HLA-DQA1 might be one of the factors influencing the individual susceptibility to TCE-induced severe generalized dermatitis.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Drug Eruptions	susceptibility	ISO	HLA-DQA1 (Homo sapiens)	8547665; 8547665	DNA:polymorphisms:exon:	RGD
Drug Eruptions	susceptibility	IAGP		8547665	DNA:polymorphisms:exon:	RGD

Objects Annotated

Genes (Rattus norvegicus)

RT1-Ba (RT1 class II, locus Ba)

Genes (Mus musculus)

H2-Aa (histocompatibility 2, class II antigen A, alpha)

Genes (Homo sapiens)

HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1)

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[Possible association between polymorphisms of human leukocyte antigen-DQ genes and susceptibility to trichloroethylene-induced severe generalized dermatitis].