RGD Reference Report - Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients. - Rat Genome Database

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Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients.

Authors: Eroglu, M  Yilmaz, N  Yalcinkaya, S  Ay, N  Aydin, O  Sezer, C 
Citation: Eroglu M, etal., Kaohsiung J Med Sci. 2013 Jul;29(7):368-73. doi: 10.1016/j.kjms.2012.11.004. Epub 2013 Jan 16.
RGD ID: 8547662
Pubmed: PMID:23768700   (View Abstract at PubMed)
DOI: DOI:10.1016/j.kjms.2012.11.004   (Journal Full-text)

Increases in the generation of reactive oxygen species and decreases in antioxidant enzyme activities with aging have been reported in the prostate, and are also observed in age-related disorders such as atherosclerosis, Alzheimer's disease, and cataracts. Several studies have demonstrated that proteins are targets for reactive oxidants in cells, and that oxidized proteins accumulate during aging, oxidative stress and in some pathological conditions. However, only a limited number of studies have actually evaluated oxidative damage in relation to HDL-cholesterol-associated antioxidant enzyme activities or have assessed its relationship with prostate cancer. In this study, we examined the effect of HDL-cholesterol-associated antioxidant enzyme activities, paraoxonase1, arylesterase and new oxidative stress parameters (total oxidant status, total antioxidant status [and oxidative stress index]) in newly-diagnosed prostate cancer patients and healthy controls. There were no significant differences in oxidative stress parameters and lipid parameters between prostate cancer patients and controls, however, paraoxonase1 enzyme activity, and non-HDL-cholesterol levels were higher in prostate cancer patients than controls. The results of this study were derived from a small number of subjects, but might represent an important working hypothesis for further research in a larger number of cases to clarify the role of paraoxonase1 overproduction on the prostate and its clinical relevance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer  IEP 8547662protein:increased activity:serum (human)RGD 
prostate cancer  ISOPON1 (Homo sapiens)8547662; 8547662protein:increased activity:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pon1  (paraoxonase 1)

Genes (Mus musculus)
Pon1  (paraoxonase 1)

Genes (Homo sapiens)
PON1  (paraoxonase 1)


Additional Information