RGD Reference Report - DQA1 and DQB1 association and nasal polyposis. - Rat Genome Database

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DQA1 and DQB1 association and nasal polyposis.

Authors: Fajardo-Dolci, G  Solorio-Abreu, J  Romero-Alvarez, JC  Zavaleta-Villa, B  Cerezo-Camacho, O  Jimenez-Lucio, R  Olivo-Diaz, A 
Citation: Fajardo-Dolci G, etal., Otolaryngol Head Neck Surg. 2006 Aug;135(2):243-7.
RGD ID: 8547658
Pubmed: PMID:16890076   (View Abstract at PubMed)
DOI: DOI:10.1016/j.otohns.2006.03.034   (Journal Full-text)

OBJECTIVE: The aim of this study was to determine the contribution of the human major histocompatibility complex (HLA)-DQA1, -DQB1, and TNFalpha genes with simple nasal polyposis. STUDY DESIGN AND SETTING: A comparative case-control study with 31 patients and 151 controls was performed. HLA-DQA1, -DQB1, and TNFalpha -238 promoter position loci were typed by polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOPs). TNFalpha -308 promoter position was determined by PCR and digestion with NcoI restriction enzyme. RESULTS: The allele HLA-DQA1*0201 (P(c) = 0.019) had an etiologic fraction (EF) of 17%, whereas 13% EF was found for the haplotype HLA-DQA1*0201-DQB1*0201 (P = 0.016). Analysis of -DQB1 and TNFalpha promoter did not show significant differences between cases and controls. CONCLUSIONS: HLA-DQA1*0201-DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease. EBM rating: B-2b.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Nasal Polyps susceptibilityISOHLA-DQA1 (Homo sapiens)8547658; 8547658DNA:polymorphism and haplotype: :HLA-DQA1*0201RGD 
Nasal Polyps susceptibilityISOHLA-DQB1 (Homo sapiens)8547658; 8547658DNA:haplotype: : HLA-DQB1*0201RGD 
Nasal Polyps susceptibilityIAGP 8547658DNA:polymorphism and haplotype: :HLA-DQA1*0201RGD 
Nasal Polyps susceptibilityIAGP 8547658DNA:haplotype: : HLA-DQB1*0201RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information