RGD Reference Report - Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans. - Rat Genome Database

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Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans.

Authors: Xiao, FL  Zhou, FS  Liu, JB  Yan, KL  Cui, Y  Gao, M  Liang, YH  Sun, LD  Zhou, SM  Zhu, YG  Zhang, XJ  Yang, S 
Citation: Xiao FL, etal., Arch Dermatol Res. 2005 Nov;297(5):201-9. Epub 2005 Nov 11.
RGD ID: 8547568
Pubmed: PMID:16231148   (View Abstract at PubMed)
DOI: DOI:10.1007/s00403-005-0608-2   (Journal Full-text)

Accumulative evidences have shown that certain HLA loci are associated with alopecia areata (AA), but with existing differences in ethnic distribution. No report has ever been published about this in Chinese Hans. To investigate whether HLA-DQA1 and DQB1 alleles are associated with AA, and the correlation of the HLA profile with age of onset, severity, duration of current attack, recurrence and family history of AA in Chinese Hans. The polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA-DQA1 and DQB1 alleles in 192 patients with AA and 273 healthy controls in Chinese Hans. The significant increased frequencies of HLA-DQA1*0104 (OR=3.38, P(c)<0.001), HLA-DQB1*0604 (OR=5.17, P(c)=0.006) and HLA-DQA1*0606 (OR=3.73, P(c)<0.001) were observed in patients compared with controls. The DQA1*0104-DQB1*0604, DQA1*0104-DQB1*0606, and DQA1*0302-DQB1*0606 were found as high-risk haplotypes in developing AA in this study. HLA-DQA1*0104 (OR=5.31, P(c)<0.001) and -DQB1*0604 (OR=5.56, P(c)=0.015) were more prevalent only in AA patients with long duration than controls. The frequencies of HLA-DQB1*0604 (OR=5.42, P(c)=0.009) and -DQB1*0606 (OR=4.11, P(c)<0.001) were obviously increased in patients less than 50% scalp hair loss. No locus was merely associated with early onset, severe involvement, recurrence and a positive family history of AA. This study demonstrated the positive association of HLA-DQA1 and DQB1 alleles and haplotypes with AA. There may be differences in genetic background in patients with different duration.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
alopecia areata susceptibilityISOHLA-DQA1 (Homo sapiens)8547568; 8547568DNA:polymorphism: : HLA-DQA1*0104 more ...RGD 
alopecia areata susceptibilityISOHLA-DQB1 (Homo sapiens)8547568; 8547568DNA:polymorphism: : HLA-DQB1*0604 and RGD 
alopecia areata susceptibilityIAGP 8547568DNA:polymorphism: : HLA-DQA1*0104 more ...RGD 
alopecia areata susceptibilityIAGP 8547568DNA:polymorphism: : HLA-DQB1*0604 and RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information