RGD Reference Report - Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis. - Rat Genome Database

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Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis.

Authors: Perna, L  Butterbach, K  Haug, U  Schottker, B  Muller, H  Arndt, V  Holleczek, B  Burwinkel, B  Brenner, H 
Citation: Perna L, etal., Cancer Epidemiol Biomarkers Prev. 2013 Mar;22(3):437-42. doi: 10.1158/1055-9965.EPI-12-0970-T. Epub 2013 Jan 8.
RGD ID: 8158069
Pubmed: PMID:23300018   (View Abstract at PubMed)
DOI: DOI:10.1158/1055-9965.EPI-12-0970-T   (Journal Full-text)

Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene. The association of VDR polymorphisms with breast cancer-specific and all-cause mortality after a breast cancer diagnosis remains, however, largely unexplored. We assessed the association of genetic variants in VDR (rs731236, rs1989969, rs2228570, and 11568820) with breast cancer survival in a sample of 498 patients with breast cancer with a mean age at diagnosis of 61 years from Saarland, Germany, who were followed for up to 5 years with respect to total and breast cancer-specific mortality (56 and 48 events, respectively). Adjusted HRs with 95% confidence intervals (CI) were estimated by Cox regression models. We found that patients with breast cancer homozygous for the rare allele of rs731236 (15% of the women in our cohort) had a tendency toward an increased risk for breast cancer-specific mortality. The HR (95% CI) adjusted for age and breast cancer stage was 2.8 (1.1-7.2) for breast cancer-specific mortality and 2.1 (0.9-4.9) for total mortality. Additional adjustment for family history of breast cancer, radical mastectomy, and body mass index only marginally changed the estimates. No association was found for rs1989969, rs2228570, and rs11568820. Our analysis suggests that VDR polymorphism rs731236 might be associated with breast cancer-specific mortality, and if our findings are confirmed in future bigger studies rs731236 might deserve consideration as a prognostic factor in clinical care of patients with breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer no_associationIAGP 8158069DNA:SNPs: :rs1989969 more ...RGD 
breast cancer no_associationISOVDR (Homo sapiens)8158069; 8158069DNA:SNPs: :rs1989969 more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vdr  (vitamin D receptor)

Genes (Mus musculus)
Vdr  (vitamin D (1,25-dihydroxyvitamin D3) receptor)

Genes (Homo sapiens)
VDR  (vitamin D receptor)


Additional Information