RGD Reference Report - Angiotensin I converting enzyme activity in adriamycin induced nephrosis in rats. - Rat Genome Database

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Angiotensin I converting enzyme activity in adriamycin induced nephrosis in rats.

Authors: Venkatesan, N  Ramesh, CV  Jayakumar, R  Chandrakasan, G 
Citation: Venkatesan N, etal., Toxicology. 1993 Dec 31;85(2-3):137-48.
RGD ID: 8157608
Pubmed: PMID:8303709   (View Abstract at PubMed)

Activity of the dipeptidyl hydrolase angiotensin converting enzyme (ACE) has been observed to be altered by treatment with adriamycin (ADR). We used an animal model of ADR nephrotoxicity to study the effects on ACE in serum, urine and tissues on days 5, 10, 15, 20, 25 and 30 after ADR administration. Both glomerular and tubular injury occurred as evidenced by heavy proteinuria, albuminuria and increased urine N-acetyl glucosaminidase (NAG) excretion. Serum ACE was significantly elevated on days 20, 25 and 30. Of great interest was the excretion of ACE in urine of treated rats which ran parallel with the total protein excretion above the barely detectable levels found in controls. ACE activity increased in kidney, adrenal gland and liver on days 15, 20, 25 and 30. Heart and brain ACE levels increased on days 25 and 30. Increased ACE activity in aorta and lungs occurred on days 20, 25 and 30. ACE activity decreased in kidney, aorta, heart and brain on days 5 and 10. These observations strongly suggest a contribution of various tissues to elevate the serum ACE level. Urinary ACE may be of potential use as an index for renal glomerular and tubular damage.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nephrosis  ISOAce (Rattus norvegicus)8157608; 8157608protein:increased activity:multiple (rats)RGD 
nephrosis  IEP 8157608protein:increased activity:multiple (rats)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information