RGD Reference Report - Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. - Rat Genome Database

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Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone.

Authors: Rhodus, NL  Cheng, B  Bowles, W  Myers, S  Miller, L  Ondrey, F 
Citation: Rhodus NL, etal., Oral Dis. 2006 Mar;12(2):112-6.
RGD ID: 7794728
Pubmed: PMID:16476030   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1601-0825.2005.01165.x   (Journal Full-text)

OBJECTIVE: To explore the potential of detecting the level of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1-alpha (IL-1-alpha), IL-6, and IL-8 in whole unstimulated saliva (WUS) in monitoring the therapeutic effects of topical dexamethasone on these salivary cytokines in subjects with erosive oral lichen planus (OLP). STUDY DESIGN: Thirteen definitively diagnosed OLP subjects were enrolled in the study as were 13 age- and sex-matched controls. The OLP subjects were treated with 0.1% dexamethasone oral rinse for 6 weeks. Prior to treatment and at the end of clinical trial, the visual analog scale (VAS) for symptoms was recorded, WUS was collected and these proinflammatory cytokines were analyzed by ELISA. RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls. VAS value was decreased significantly and was found to significantly correlate with the decrease in IL-1-alpha and IL-8 levels. CONCLUSIONS: These preliminary results indicate that salivary analysis of NF-kappaB-dependent cytokines may be applied to monitoring the therapeutic response of OLP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oral Lichen Planus treatmentIEP 7794728 RGD 
Oral Lichen Planus treatmentISOIL1A (Homo sapiens)7794728; 7794728 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)


Additional Information