RGD Reference Report - Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus. - Rat Genome Database

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Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus.

Authors: Ichimura, M  Hiratsuka, K  Ogura, N  Utsunomiya, T  Sakamaki, H  Kondoh, T  Abiko, Y  Otake, S  Yamamoto, M 
Citation: Ichimura M, etal., J Oral Pathol Med. 2006 Mar;35(3):167-74.
RGD ID: 7483584
Pubmed: PMID:16454813   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1600-0714.2006.00402.x   (Journal Full-text)

BACKGROUND: To understand the immunopathological features of oral lichen planus (OLP), we analyzed the expression of chemokines in the epithelial cell layers. Methods: Epithelia from OLP or healthy gingiva were collected by laser microdissection. The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray. RESULTS: High levels of MIP-3alpha/LARC/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC-CK1/CCL18, ELC/CCL19, SDF-1/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11) and CCR5 (e.g. RANTES/CCL5). CONCLUSIONS: Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oral Lichen Planus  IEP 7483584; 7483584 RGD 
Oral Lichen Planus  ISOCCL20 (Homo sapiens)7483584; 7483584 RGD 
Oral Lichen Planus  ISOCCR6 (Homo sapiens)7483584; 7483584 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Mus musculus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Homo sapiens)
CCL20  (C-C motif chemokine ligand 20)
CCR6  (C-C motif chemokine receptor 6)


Additional Information