RGD Reference Report - Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement. - Rat Genome Database

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Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement.

Authors: Usumi-Fujita, R  Hosomichi, J  Ono, N  Shibutani, N  Kaneko, S  Shimizu, Y  Ono, T 
Citation: Usumi-Fujita R, etal., Angle Orthod. 2013 Jan;83(1):48-56. doi: 10.2319/011712-45.1. Epub 2012 Jun 18.
RGD ID: 7421608
Pubmed: PMID:22716278   (View Abstract at PubMed)
PMCID: PMC4037556   (View Article at PubMed Central)
DOI: DOI:10.2319/011712-45.1   (Journal Full-text)

OBJECTIVE: To examine changes in microvasculature and the expression of vascular endothelial growth factor A (VEGF-A) and VEGF receptor 2 (VEGFR-2) in rat hypofunctional periodontal ligament (PDL) during experimental tooth movement. MATERIALS AND METHODS: Twelve-week-old male Sprague-Dawley rats were divided into normal occlusion and occlusal hypofunction groups. After a 2-week bite-raising period, rat first molar was moved mesially using a 10-gf titanium-nickel alloy closed coil spring in both groups. On days 0, 1, 2, 3, and 7 after tooth movement, histologic changes were examined by micro-computed tomography and immunohistochemistry using CD31, VEGF-A, VEGFR-2, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method. RESULTS: Hypofunctional molars inclined more than normal molars and did not move notably after day 1 of tooth movement. Blood vessels increased on the tension side of the PDL in normal teeth. Immunoreactivities for VEGF-A and VEGFR-2 in normal teeth were greater than those in hypofunctional teeth during tooth movement. Compressive force rapidly caused apoptosis of the PDL and vascular endothelial cells in hypofunctional teeth, but not in normal teeth. CONCLUSIONS: Occlusal hypofunction induces vascular constriction through a decrease in the expression of VEGF-A and VEGFR-2, and apoptosis of the PDL and vascular cells occurs during tooth movement.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Periodontal Atrophy  ISOVegfa (Rattus norvegicus)7421608; 7421608protein:decreased expression:maxilla:RGD 
Periodontal Atrophy  IEP 7421608protein:decreased expression:maxilla:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information