RGD Reference Report - Genomic regions controlling corticosterone levels in rats. - Rat Genome Database

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Genomic regions controlling corticosterone levels in rats.

Authors: Potenza, MN  Brodkin, ES  Joe, B  Luo, X  Remmers, EF  Wilder, RL  Nestler, EJ  Gelernter, J 
Citation: Potenza MN, etal., Biol Psychiatry 2004 Mar 15;55(6):634-41.
RGD ID: 737981
Pubmed: PMID:15013833   (View Abstract at PubMed)
DOI: DOI:10.1016/j.biopsych.2003.11.005   (Journal Full-text)

BACKGROUND: The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness. METHODS: Rat strains, F344/NHsd and LEW/NHsd, which differ in measures of stress-responsiveness and behaviors modeling psychiatric disorders, were bred to generate F2 progeny that were used in a quantitative trait loci (QTL) analysis to identify genomic regions influencing late-afternoon corticosterone levels. RESULTS: Regions on chromosomes 4 and 10 previously identified as influencing autoimmune phenomena were the most significant QTL observed, reaching suggestive significance at the genome-wide level. Congenic animals targeting these regions with F344/NHsd deoxyribonucleic acid on a DA/Bkl genomic background demonstrated corticosterone levels approximating those of F344/NHsd rats and differing significantly from DA/Bkl rats. CONCLUSIONS: Specific genomic regions influence both corticosterone levels and stress-related disease susceptibility. These findings not only represent the first identification of QTL controlling corticosterone levels but also suggest a mechanism underlying genetic differences in stress-responsiveness.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased circulating corticosterone level  QTM 737981; 737981 RGD 

Objects Annotated

QTLs
Stresp4  (Stress response QTL 4)
Stresp5  (Stress response QTL 5)

Strains
F344/NHsd  (F344/NHsd)
LEW/NHsd  (NA)

Objects referenced in this article
Strain DA.F344(Cia3c)/Arb null Rattus norvegicus
Strain DA.F344(Cia3e)/Arb null Rattus norvegicus
Strain DA.F344-(D4Arb30-D4Arb4)/Arb null Rattus norvegicus
Strain DA.F344-(D4Got44-D4Arb21)/Arb null Rattus norvegicus
Strain DA.F344-(D4Got44-D4Rat128)/Arb null Rattus norvegicus
Strain DA.F344-(D4Uia2-D4Wox21)/Arb null Rattus norvegicus
Strain DA/Bkl null Rattus norvegicus
Strain LEW/NHsdCpb null Rattus norvegicus

Additional Information