RGD Reference Report - The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. - Rat Genome Database

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The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development.

Authors: Sibilia, M  Fleischmann, A  Behrens, A  Stingl, L  Carroll, J  Watt, FM  Schlessinger, J  Wagner, EF 
Citation: Sibilia M, etal., Cell 2000 Jul 21;102(2):211-20.
RGD ID: 734919
Pubmed: PMID:10943841   (View Abstract at PubMed)

The EGF receptor (EGFR) is required for skin development and is implicated in epithelial tumor formation. Transgenic mice expressing a dominant form of Son of Sevenless (SOS-F) in basal keratinocytes develop skin papillomas with 100% penetrance. However, tumor formation is inhibited in a hypomorphic (wa2) and null EGFR background. Similarly, EGFR-deficient fibroblasts are resistant to transformation by SOS-F and rasV12, however, tumorigenicity is restored by expression of the anti-apoptotic bcl-2 gene. The K5-SOS-F papillomas and primary keratinocytesfrom wa2 mice display increased apoptosis, reduced Akt phosphorylation and grafting experiments imply a cell-autonomous requirement for EGFR in keratinocytes. Therefore, EGFR functions as a survival factor in oncogenic transformation and provides a valuable target for therapeutic intervention in a broader range of tumors than anticipated.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
papilloma susceptibilityISOEgfr (Mus musculus)734919; 734919 RGD 
papilloma susceptibilityIMP 734919 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)


Additional Information