RGD Reference Report - The H-cadherin (CDH13) gene is inactivated in human lung cancer. - Rat Genome Database

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The H-cadherin (CDH13) gene is inactivated in human lung cancer.

Authors: Sato, M  Mori, Y  Sakurada, A  Fujimura, S  Horii, A 
Citation: Sato M, etal., Hum Genet 1998 Jul;103(1):96-101.
RGD ID: 734736
Pubmed: PMID:9737784   (View Abstract at PubMed)

We have previously reported frequent allelic loss in chromosome bands 16q24.1-q24.2 in human lung cancer. Since the H-cadherin (CDH13) gene has been isolated and mapped to this common region of allelic loss, we have investigated this gene in human lung cancer. The reverse transcription/polymerase chain reaction technique has revealed the loss of expression in four (57%) of seven lung cancer cell lines. To study the CDH13 gene further, we have analyzed deletions, genetic alterations, and methylation status at the 5' region of this gene. Three (75%) of four cell lines that have lost expression show a deletion of the CDH13 locus accompanied by hypermethylation of the remaining allele. Moreover, hypermethylation has been observed in nine (45%) of 20 primary lung cancers. These results suggest that a combination of deletion and hypermethylation causes inactivation of the CDH13 gene in a considerable number of human lung cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lung Neoplasms  IAGP 734736 RGD 
Lung Neoplasms  ISOCDH13 (Homo sapiens)734736; 734736 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdh13  (cadherin 13)

Genes (Mus musculus)
Cdh13  (cadherin 13)

Genes (Homo sapiens)
CDH13  (cadherin 13)


Additional Information