RGD Reference Report - Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. - Rat Genome Database

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Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia.

Authors: Matsuda, Y  Saegusa, H  Zong, S  Noda, T  Tanabe, T 
Citation: Matsuda Y, etal., Biochem Biophys Res Commun 2001 Dec 14;289(4):791-5.
RGD ID: 734670
Pubmed: PMID:11735114   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.6051   (Journal Full-text)

To investigate the functional role of Ca(v)2.3 channel in glucose homeostasis, we performed in vivo glucose tolerance and insulin tolerance tests together with stress-induced glucose release tests using mice deficient in Ca(v)2.3 channel (Ca(v)2.3-/-). The Ca(v)2.3-/- mice were significantly heavier than wild-type mice. In glucose tolerance and insulin tolerance tests, Ca(v)2.3-/- mice showed a significantly higher blood glucose level compared to wild-type mice. However, stress-induced blood glucose changes in Ca(v)2.3-/- mice were similar to those in wild-type mice. These results suggest that Ca(v)2.3 channel plays a role in glucose homeostasis by reducing insulin sensitivity and that Ca(v)2.3-/- mice exhibit symptoms resembling non-insulin-dependent diabetes mellitus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperglycemia  ISOCacna1e (Mus musculus)734670; 734670 RGD 
hyperglycemia  IMP 734670 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cacna1e  (calcium voltage-gated channel subunit alpha1 E)

Genes (Mus musculus)
Cacna1e  (calcium channel, voltage-dependent, R type, alpha 1E subunit)

Genes (Homo sapiens)
CACNA1E  (calcium voltage-gated channel subunit alpha1 E)


Additional Information