RGD Reference Report - Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. - Rat Genome Database

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Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells.

Authors: Mizuta, M  Inagaki, N  Nemoto, Y  Matsukura, S  Takahashi, M  Seino, S 
Citation: Mizuta M, etal., J Biol Chem 1994 Apr 22;269(16):11675-8.
RGD ID: 730118
Pubmed: PMID:8163462   (View Abstract at PubMed)

Synaptotagmin (p65), an integral membrane protein of synaptic vesicles, is thought to be involved in calcium-dependent exocytosis of synaptic vesicles. Here, we report the cloning and tissue distribution of a novel isoform of synaptotagmin, designated synaptotagmin III. The cDNA clones encoding synaptotagmin III have been isolated from a rat brain cDNA library. Rat synaptotagmin III is a protein of 588 amino acids having 40.5, 38.3, and 64.0% identity with rat synaptotagmin I, rat synaptotagmin II, and o-p65-C, a third synaptotagmin isoform of marine ray Discopyge ommata, respectively. The region of the two internal repeats homologous to the regulatory domain (C2 domain) of protein kinase C is highly conserved among synaptotagmin I, II, and III. RNA blotting studies reveal that synaptotagmin III mRNA is expressed in brain, various endocrine tissues, and hormone-secreting clonal cells. These results suggest that rat synaptotagmin III is a mammalian homolog of o-p65-C and is involved in Ca(2+)-dependent exocytosis of secretory vesicles in endocrine cells, as well as in neurons.

Objects referenced in this article
Gene Syt3 synaptotagmin 3 Rattus norvegicus

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