RGD Reference Report - Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system.

Authors: Thompson, CC  Weinberger, C  Lebo, R  Evans, RM 
Citation: Thompson CC, etal., Science 1987 Sep 25;237(4822):1610-4.
RGD ID: 730105
Pubmed: PMID:3629259   (View Abstract at PubMed)

A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.

Objects referenced in this article
Gene Thra thyroid hormone receptor alpha Rattus norvegicus
Gene Thra_v1 thyroid hormone receptor alpha, variant 1 Rattus norvegicus

Additional Information