RGD Reference Report - Expression and activity of the POU transcription factor SCIP. - Rat Genome Database

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Expression and activity of the POU transcription factor SCIP.

Authors: Monuki, ES  Kuhn, R  Weinmaster, G  Trapp, BD  Lemke, G 
Citation: Monuki ES, etal., Science 1990 Sep 14;249(4974):1300-3.
RGD ID: 729555
Pubmed: PMID:1975954   (View Abstract at PubMed)

POU proteins have been shown to transcriptionally active cell-specific genes and to participate in the determination of cell fate. It is therefore thought that these proteins function in development through the stable activation of genes that define specific developmental pathways. Evidence is provided here for an alternative mode of action. The primary structure of SCIP, a POU protein expressed by developing Schwann cells of the peripheral nervous system, was deduced and SCIP activity was studied. Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation. In cotransfection assays, SCIP acted as a transcriptional repressor of myelin-specific genes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glial cell differentiation  IDA 729555 RGD 
negative regulation of DNA-templated transcription  IDA 729555 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pou3f1  (POU class 3 homeobox 1)

Objects referenced in this article
Gene Pou3f2 POU class 3 homeobox 2 Rattus norvegicus

Additional Information