RGD Reference Report - A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. - Rat Genome Database

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A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration.

Authors: Ono, F  Nakagawa, T  Saito, S  Owada, Y  Sakagami, H  Goto, K  Suzuki, M  Matsuno, S  Kondo, H 
Citation: Ono F, etal., J Biol Chem 1998 Mar 27;273(13):7731-6.
RGD ID: 729517
Pubmed: PMID:9516481   (View Abstract at PubMed)

We report herein the cloning and characterization of a novel class II phosphoinositide 3-kinase, termed PI3K-IIgamma, from the cDNA library of regenerating rat liver. This cDNA encodes a protein of 1505 amino acids with a calculated molecular mass of 170,972 Da. The amino acid sequence of PI3K-IIgamma is highly similar to those of class II PI 3-kinases, including murine Cpk-m/p170 and human HsC2-PI3K. It contains a C2 domain at the C terminus but no recognizable protein motifs at its N terminus. PI3K-IIgamma displays a restricted substrate specificity for PtdIns and PtdIns 4-P, but not for PtdIns 4,5-P2. By epitope tag immunocytochemistry, the immunoreactivity for PI3K-IIgamma is localized in the juxtanuclear Golgi region at high levels and also in the plasma and nuclear membranes at low levels. By Northern blot analysis and in situ hybridization histochemistry, PI3K-IIgamma mRNA expression is confined to the liver throughout the development with much higher expression in adult liver than in fetal liver. In addition, its expression increases during liver regeneration after partial hepatectomy with maximal expression after the growth period, suggesting that PI3K-IIgamma may function mainly in highly differentiated hepatic cells.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
phosphatidylinositol-3-phosphate biosynthetic process involved_inIDA 729517PMID:9516481UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nuclear envelope  IDA 729517 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Pik3c2g  (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma)


Additional Information