RGD Reference Report - Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit. - Rat Genome Database

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Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.

Authors: Heinemann, SH  Rettig, J  Wunder, F  Pongs, O 
Citation: Heinemann SH, etal., FEBS Lett 1995 Dec 27;377(3):383-9.
RGD ID: 729192
Pubmed: PMID:8549760   (View Abstract at PubMed)
DOI: DOI:10.1016/0014-5793(95)01377-6   (Journal Full-text)

A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.

Objects referenced in this article
Gene Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 Rattus norvegicus

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