RGD Reference Report - Lamin A gene expression is specifically suppressed in v-src-transformed cells. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Lamin A gene expression is specifically suppressed in v-src-transformed cells.

Authors: Ozaki, T  Sakiyama, S 
Citation: Ozaki T and Sakiyama S, FEBS Lett 1992 Nov 9;312(2-3):165-8.
RGD ID: 729133
Pubmed: PMID:1426247   (View Abstract at PubMed)

By a differential screening procedure, we have obtained several cDNAs the expression of which was down-regulated in v-src-transformed 3Y1 cells compared to parental 3Y1 cells. One of these cDNAs, termed N26, was extensively analyzed. Sequence analysis revealed that N26 cDNA was 3,095 nucleotides in length and contained an open reading frame of 665 amino acid residues. Based on an homology search at the nucleotide level, it was postulated that N26 gene encodes lamin A. The expression of the N26 gene was not suppressed in other types of transformed cells, such as v-mos-, v-ras- and SV40-transformed 3Y1 cells.

Objects referenced in this article
Gene Lmna lamin A/C Rattus norvegicus

Additional Information