RGD Reference Report - Regulation of GHRH receptor gene expression in the neonatal and adult rat pituitary. - Rat Genome Database

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Regulation of GHRH receptor gene expression in the neonatal and adult rat pituitary.

Authors: Korytko, AI  Cuttler, L 
Citation: Korytko AI and Cuttler L, Growth Horm IGF Res 2001 Oct;11(5):282-8.
RGD ID: 728842
Pubmed: PMID:11735246   (View Abstract at PubMed)
DOI: DOI:10.1054/ghir.2001.0238   (Journal Full-text)

The growth hormone releasing hormone (GHRH) receptor gene is essential for normal growth, and its expression is developmentally regulated. The factors that control GHRH receptor expression in the neonatal pituitary are not well understood. This study focuses on the regulation of GHRH receptor gene expression by thyroid hormone, glucocorticoids, insulin-like growth factor-I (IGF-I) and IGF-II in rat pituitary cell cultures. In newborn pituitaries, both T3 and hydrocortisone (24 h) caused a dose-dependent increase in GHRH receptor mRNA abundance, reaching levels 4.8-fold (P<0.001) and 6.5-fold (P<0.001) over corresponding controls. T3 and hydrocortisone also stimulated GHRH receptor expression in adult (70 day) pituitary cell cultures, consistent with our earlier findings. IGF-I treatment suppressed the inductive effects of T3 (P<0.02) and hydrocortisone (P<0.03) on GHRH receptor expression in adult pituitaries but not in neonatal pituitaries. Unlike IGF-I, IGF-II treatment had no effect on T3-induced or hydrocortisone-induced GHRH receptor expression in either neonates or adults. Taken together, these results indicate that (1) thyroid hormone and hydrocortisone act directly at the neonatal pituitary as potent stimulators of GHRH receptor gene expression, (2) IGF-I, but not IGF-II, acts at the pituitary to suppress GHRH receptor mRNA expression and (3) the effects of IGF-I on GHRH receptor gene expression are developmentally determined.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of growth  TAS 728842 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghrhr  (growth hormone releasing hormone receptor)


Additional Information