RGD Reference Report - Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus. - Rat Genome Database

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Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus.

Authors: Suzuki, R  Shimojima, H  Funahashi, H  Nakajo, S  Yamada, S  Guan, JL  Tsurugano, S  Uehara, K  Takeyama, Y  Kikuyama, S  Shioda, S 
Citation: Suzuki R, etal., Neurosci Lett 2002 May 10;324(1):5-8.
RGD ID: 728687
Pubmed: PMID:11983281   (View Abstract at PubMed)

Immunohistochemistry and Western blotting were used to determine the distribution of orexin receptors in the rat brain. Strong orexin receptor 1 (OX1R) immunoreactivity was detected in the hypothalamus including the arcuate, ventromedial, and tuberomammillary nuclei that are involved in feeding regulation. The neuropeptide Y- and proopiomelanocortin-containing neurons of the arcuate nucleus, which act to stimulate or to inhibit feeding, respectively, displayed intense OX1R immunoreactivity by double immunostaining. Western blotting analysis yielded a 50-kDa major band of OX1R.

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Gene Hcrtr1 hypocretin receptor 1 Rattus norvegicus

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