RGD Reference Report - Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. - Rat Genome Database

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Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure.

Authors: Carr, FJ  Negrin, CD  Clark, JS  Graham, D  McBride, MW  Anderson, NW  Dominiczak, AF 
Citation: Carr FJ, etal., Scott Med J 2002 Feb;47(1):7-9.
RGD ID: 728179
Pubmed: PMID:11980293   (View Abstract at PubMed)

The localisation of quantitative trait loci (QTL) is the first step towards gene identification. This is then verified by the construction of reciprocal congenic strains. The hypertensive SHRSP and normotensive WKY strains were used in a speed congenic approach to confirm the existence of a QTL on rat chromosome 2. Systolic baseline and salt loaded blood pressures were measured by radiotelemetry. Transfer of the chromosome 2 blood pressure QTL region from WKY into an SHRSP background significantly reduced blood pressure, with the increased significance at the salt loaded period, compared to the SHRSP. The reciprocal congenic blood pressure showed a significantly increased baseline systolic pressure compared to the WKY, with no change in significance at the salt loaded period. Thus we have successfully captured a gene(s) which contribute to blood pressure regulation in both congenic strains. This will facilitate further positional cloning of the causative genes first in this model and then in human essential hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 728179; 728179; 728179 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Bp164  (Blood pressure QTL 164)
Bp165  (Blood pressure QTL 165)
Bp166  (Blood pressure QTL 166)

Objects referenced in this article
QTL Bp10 Blood pressure QTL 10 Rattus norvegicus
QTL Bp14 Blood pressure QTL 14 Rattus norvegicus
QTL Bp16 Blood pressure QTL 16 Rattus norvegicus
QTL Bp19 Blood pressure QTL 19 Rattus norvegicus

Additional Information