RGD Reference Report - Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision.

General

Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision.
Authors:	Matsui, F Kawashima, S Shuo, T Yamauchi, S Tokita, Y Aono, S Keino, H Oohira, A
Citation:	Matsui F, etal., Neuroscience 2002;112(4):773-81.
RGD ID:	727637
Pubmed:	PMID:12088737 (View Abstract at PubMed)
Neurocan is one of the major chondroitin sulfate proteoglycans expressed in nervous tissues. The expression of neurocan is developmentally regulated, and full-length neurocan is detected in juvenile brains but not in adult brains. In the present study, we demonstrated by western blot analysis that full-length neurocan transiently appeared in adult rat hippocampus when it was lesioned by kainate-induced seizures. Immunohistochemical studies showed that neurocan was detected mainly around the CA1 region although the seizure resulted in neuronal cell degeneration in both the CA1 and CA3 regions of the hippocampus. Double-labeling for neurocan mRNA and glial fibrillary acidic protein demonstrated that many reactive astrocytes expressed neurocan mRNA. The re-expression of full-length neurocan was also observed in the surgically injured adult rat brain. In contrast, the expression of other nervous tissue chondroitin sulfate proteoglycans, such as phosphacan and neuroglycan C, was not intensified but rather was either reduced in the kainate-lesioned hippocampus or in the surgically injured cerebral cortex. These observations indicate that induction of neurocan expression by reactive astrocytes is a common phenomenon in the repair process of adult brain injury, and therefore, it can be postulated that juvenile-type neurocan plays some roles in brain repair.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Brain Injuries		ISO	Ptprz1 (Rattus norvegicus)	727637; 727637		RGD
Brain Injuries		IEP		727637		RGD

Objects Annotated

Genes (Rattus norvegicus)

Ptprz1 (protein tyrosine phosphatase, receptor type Z1)

Genes (Mus musculus)

Ptprz1 (protein tyrosine phosphatase receptor type Z, polypeptide 1)

Genes (Homo sapiens)

PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Objects referenced in this article

Gene	Ncan	neurocan	Rattus norvegicus

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Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision.