RGD Reference Report - Cloning and expression of the programmed cell death regulator Bad in the rat brain. - Rat Genome Database

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Cloning and expression of the programmed cell death regulator Bad in the rat brain.

Authors: D'Agata, V  Magro, G  Travali, S  Musco, S  Cavallaro, S 
Citation: D'Agata V, etal., Neurosci Lett 1998 Feb 27;243(1-3):137-40.
RGD ID: 727627
Pubmed: PMID:9535132   (View Abstract at PubMed)

The Bcl-2 family of proteins consists of both antagonists (e.g. Bcl-2) and agonists (e.g. Bax) that regulate apoptosis and compete through dimerization. In the present study we cloned the cDNA encoding the rat brain BAD, a distant member of the Bcl-2 family that was shown to promote cell death. The cloned cDNA encoded a protein of 205 amino acids, containing three putative Bcl-2 homology domains (BH1, BH2 and BH3) and no C-terminal signal-anchor sequence. The predicted amino acid sequence was identical to the Bad-cDNA recently cloned from the rat ovary with the exception of a stretch of six amino acids, thus indicating the existence of two Bad alternative splice variants or a sequence artifact in the rat ovary Bad-cDNA. Immunohistochemical analysis in the rat brain revealed the exclusive expression of Bad in the epithelial cells of the choroid plexus, a result which is consistent with a very specialized function of Bad in the brain.

Objects referenced in this article
Gene Bad BCL2-associated agonist of cell death Rattus norvegicus

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